Clinical use of contrast agents to enhance skin structures in reflectance and fluorescence confocal microscopy and optical coherence tomography: a systematic review and patient cases

Jun
24
2019

European Conferences on Biomedical Optics (ECBO) > Preclinical and Clinical Optical Diagnostics > Lunch Break and Poster Session - Monday

24. Jun 2019
12:45-14:15 h  |  Hall B0 Hall B0, ICM

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Subjects: 

Biophotonics and Medical Engineering

Participants: 

Mette Mogensen 

(Bispebjerg Hospital)

Type:
Poster
Speech: English
Distinction between normal skin architecture and pathology can be a diagnostic challenge for Dermatologists. It is illustrated in two clinical cases and in a review summarizing how various exogenous chemical and physical contrast agents, either topically delivered, or injected into the skin affect distinction between skin disease and normal skin using optical coherence tomography (OCT) and confocal microscopy (CM). A systematic review of in vivo OCT and CM studies using exogenous contrast agents on healthy human skin and skin disease, using Embase and Medline databases was performed. Quality assessment of eligible studies was undertaken. The initial search identified 86 unique references and 8 CM studies (164 patients) and 1 OCT study (11 patients) were eligible. Four contrast agents aluminum chloride (AlCl) n=2, indocyanin green (ICG) n=3, sodium fluorescein n=2 and acetic acid n=1 applied to CM in variety of skin diseases. ICG, acetic acid and AlCl showed promise to increase contrast of tumor nests in keratinocyte carcinomas. Fluorescein and ICG enhanced contrast of keratinocytes and adnexal structures. In OCT of healthy skin gold nanoshells, increased contrast of natural skin openings. All studies were small with low levels of evidence. Three cases illustrate enhancement of skin morphology by gold nanoshells in acne and ICG and fluorescein in laser channels in normal skin. Conclusively, acetic acid, ICG and AlCl may improve delineation of skin cancers in CM; gold nanoshells facilitate visualization of adnexal structures in OCT. Further studies with robust methodological quality are necessary to implement contrast agents into routine dermatological practice.

Author
Mette Mogensen, Bispebjerg Hospital Show Profile

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ICM -InternationalesCongressCenterMünchen
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Outdoor areas
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ConferenceCenter Nord
ICM
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Jun
24
2019

European Conferences on Biomedical Optics (ECBO) > Preclinical and Clinical Optical Diagnostics > Lunch Break and Poster Session - Monday

Analysis of modern non-invasive methods of optoelectronic control of the skin

24. Jun 2019
12:45-14:15 h  |  Hall B0 Hall B0, ICM

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Jun
24
2019

European Conferences on Biomedical Optics (ECBO) > Preclinical and Clinical Optical Diagnostics > Lunch Break and Poster Session - Monday

In vivo multimodal fibre-probe spectroscopy for glioblastoma detection in mouse model

24. Jun 2019
12:45-14:15 h  |  Hall B0 Hall B0, ICM

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Jun
24
2019

European Conferences on Biomedical Optics (ECBO) > Diffuse Optical Spectroscopy and Imaging > Lunch Break and Poster Session - Monday

Spatial-frequency-domain optical tomography in the radiative transport regime

24. Jun 2019
12:45-14:15 h  |  Hall B0 Hall B0, ICM

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Jun
24
2019

European Conferences on Biomedical Optics (ECBO) > Diffuse Optical Spectroscopy and Imaging > Lunch Break and Poster Session - Monday

Pathlength distribution of (sub)diffusively reflected light

24. Jun 2019
12:45-14:15 h  |  Hall B0 Hall B0, ICM

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Jun
24
2019

European Conferences on Biomedical Optics (ECBO) > Diffuse Optical Spectroscopy and Imaging > Lunch Break and Poster Session - Monday

Influence of optical path length on multi-wavelength measurement of oxy- and deoxy-hemoglobins in the skin

24. Jun 2019
12:45-14:15 h  |  Hall B0 Hall B0, ICM

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