In vivo multimodal fibre-probe spectroscopy for glioblastoma detection in mouse model

Jun
24
2019

European Conferences on Biomedical Optics (ECBO) > Preclinical and Clinical Optical Diagnostics > Lunch Break and Poster Session - Monday

24. Jun 2019
12:45-14:15 h  |  Hall B0 Hall B0, ICM

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Subjects: 

Biophotonics and Medical Engineering

Participants: 

Enrico Baria 

(Istituto Nazionale di Ottica)

Type:
Poster
Speech: English
Glioblastoma (GBM) is the most common and aggressive malignant brain tumour in adults. Patient survival rates are strongly dependent on the successfully resection of the tumour. In this framework, multimodal optical spectroscopy could provide a fast and label-free tool for improving tumour detection and guiding the removal of diseased tissue. In this study, we used an optical fibre-probe system combining multiple spectroscopic techniques for in vivo examination of normal and GBM tissues in mouse brain. Specifically, the probe – based on a fibre-bundle with optical fibres of various size and properties – allowed performing spectroscopic measurements based on fluorescence, Raman, and diffuse reflectance spectroscopy though two optical windows implanted on the head of each animal. Two visible laser diodes were used for fluorescence spectroscopy, a laser diode emitting in the NIR was used for Raman spectroscopy, and a fibre-coupled halogen lamp for diffuse reflectance. All spectral recordings were done when the animals were anesthetized; optical inspection required less than 4 minutes for each animal. The recorded data were analysed using Principal Component Analysis (PCA) for obtaining an automated classification of the examined tissues based on the intrinsic spectral information provided by Raman and reflectance spectroscopy. The presented method demonstrated high sensitivity and specificity in discriminating GBM from normal brain. Furthermore, we found that the multimodal approach is crucial for improving diagnostic capabilities beyond what can be achieved from individual techniques.

Author
Enrico Baria, Istituto Nazionale di Ottica Show Profile

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Outdoor areas
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ICM
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Jun
24
2019

European Conferences on Biomedical Optics (ECBO) > Preclinical and Clinical Optical Diagnostics > Lunch Break and Poster Session - Monday

Analysis of modern non-invasive methods of optoelectronic control of the skin

24. Jun 2019
12:45-14:15 h  |  Hall B0 Hall B0, ICM

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Jun
24
2019

European Conferences on Biomedical Optics (ECBO) > Preclinical and Clinical Optical Diagnostics > Lunch Break and Poster Session - Monday

Clinical use of contrast agents to enhance skin structures in reflectance and fluorescence confocal microscopy and optical coherence tomography: a systematic review and patient cases

24. Jun 2019
12:45-14:15 h  |  Hall B0 Hall B0, ICM

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Jun
24
2019

European Conferences on Biomedical Optics (ECBO) > Diffuse Optical Spectroscopy and Imaging > Lunch Break and Poster Session - Monday

Spatial-frequency-domain optical tomography in the radiative transport regime

24. Jun 2019
12:45-14:15 h  |  Hall B0 Hall B0, ICM

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Jun
24
2019

European Conferences on Biomedical Optics (ECBO) > Diffuse Optical Spectroscopy and Imaging > Lunch Break and Poster Session - Monday

Pathlength distribution of (sub)diffusively reflected light

24. Jun 2019
12:45-14:15 h  |  Hall B0 Hall B0, ICM

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Jun
24
2019

European Conferences on Biomedical Optics (ECBO) > Diffuse Optical Spectroscopy and Imaging > Lunch Break and Poster Session - Monday

Influence of optical path length on multi-wavelength measurement of oxy- and deoxy-hemoglobins in the skin

24. Jun 2019
12:45-14:15 h  |  Hall B0 Hall B0, ICM

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